Yesterday I had so many kernel panics on an Intel i7 running Sequioa 15.2 with zfs-macOS-2.2.3rc5 that it was panicking before I was able to view problem message. The ones I was able to read referenced apfs again.
The panics stopped when I disconnected the enclosures for my zfs array. I noticed that 2.2.3 'proper' had been released. So installed that, connected things back up and it seems happy and stable again. I left a disk speed test running overnight and *touches a lot of wood* no issues so far.
All rather circumstantial and nothing to say it was definitely zfs-macOS-2.2.3rc5 but may help someone with a similar issue.
Kind regards,
Benjamin